Translesion DNA polymerases Pol zeta, Pol eta, Pol iota, Pol kappa and Rev1 are not essential for repeat-induced point mutation in Neurospora crassa.
J Biosci
;
2006 Dec; 31(5): 557-64
Article
in English
| IMSEAR
| ID: sea-111240
ABSTRACT
Pol zeta, Pol eta, Pol iota, Pol kappa and Rev1 are specialized DNA polymerases that are able to synthesize DNA across a damaged template. DNA synthesis by such translesion polymerases can be mutagenic due to the miscoding nature of most damaged nucleotides. In fact, many mutational and hypermutational processes in systems ranging from yeast to mammals have been traced to the activity of such polymerases. We show however, that the translesion polymerases are dispensable for repeat-induced point mutation (RIP) in Neurospora crassa. Additionally, we demonstrate that the upr-1 gene, which encodes the catalytic subunit of Pol zeta, is a highly polymorphic locus in Neurospora.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
DNA Damage
/
Fungal Proteins
/
Molecular Sequence Data
/
Base Sequence
/
Mutagenesis, Site-Directed
/
Open Reading Frames
/
Sequence Analysis, DNA
/
Point Mutation
/
Protein Subunits
Language:
English
Journal:
J Biosci
Year:
2006
Type:
Article
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