Genotype, phenotype and cancer: role of low penetrance genes and environment in tumour susceptibility.
J Biosci
;
2005 Feb; 30(1): 93-102
Article
in English
| IMSEAR
| ID: sea-111267
ABSTRACT
Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenotype
/
Humans
/
Penetrance
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Genetic Determinism
/
Epigenesis, Genetic
/
Environment
/
Genotype
/
Life Style
Type of study:
Prognostic study
Language:
English
Journal:
J Biosci
Year:
2005
Type:
Article
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