A prospective study evaluating surgery and chemo radiation in muscle invasive bladder cancer.
J Cancer Res Ther
;
2007 Apr-Jun; 3(2): 81-5
Article
in English
| IMSEAR
| ID: sea-111413
ABSTRACT
AIM:
The aim of our study was to compare the two standard treatment approaches in muscle invasive carcinoma of urinary bladder--radical cystectomy and chemo radiation. MATERIALS ANDMETHODS:
Transitional cell carcinoma (TCC) of bladder of stages, T2 to T4, N0/N1/N2 and M0 were included in the study. Patients were allotted to two arms of the study. Arm A consisted of radical cystectomy. Adjuvant CMV chemotherapy was given for T3/T4 or Node positive disease only. Arm B received 2 cycles of neoadjuvant CMV chemo therapy followed by concurrent chemo radiation.RESULTS:
Forty-four patients were recruited into the study. Thirty patients in the surgical arm and 13 patients in the chemo radiation arm. The actuarial two-year survival rate in surgical arm is 56% while in chemo radiation arm it is 54%. There was no statistically significant difference in disease-free survival also between the two groups.CONCLUSION:
Chemo radiation yielded equivalent survival results with radical cystectomy. So it is worth giving preference to chemo radiation that will give a better quality of life for the patient.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Urinary Bladder Neoplasms
/
Aged, 80 and over
/
Aged
/
Humans
/
Male
/
Carcinoma, Transitional Cell
/
Treatment Outcome
/
Muscle Neoplasms
/
Adult
/
Middle Aged
Type of study:
Observational study
Limits:
Aged80
Language:
English
Journal:
J Cancer Res Ther
Journal subject:
Neoplasms
/
Therapeutics
Year:
2007
Type:
Article
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