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Surface and antitumor activity of some novel metal-based cationic surfactants.
J Cancer Res Ther ; 2007 Oct-Dec; 3(4): 198-206
Article in English | IMSEAR | ID: sea-111538
ABSTRACT
The development of anticancer metal-based drugs was attempted by reacting dodecyl amine with selenious acid to produce a quaternary ammonium salt which was then converted to copper and cobalt cationic complexes via complexing the first compounds with copper (II) or cobalt (II) ions. The surface properties of these surfactants were investigated. The surface properties studied included critical micelle concentration (CMC), maximum surface excess (Gamma max ), and minimum surface area (A min ). Free energy of micellization (Delta G degree mic ) and adsorption (Delta G degree ads ) were calculated. Antitumor activity was tested by using Ehrlich ascites carcinoma (EAC) as a model system of mice cell tumor. The compounds were also tested in vitro on five human monolayer tumor cell lines MCF 7 (breast carcinoma), HEPG 2 (liver carcinoma), U 251 (brain tumor), HCT 116 (colon carcinoma), and H 460 (lung carcinoma). FTIR spectra, elemental analysis, and H 1 NMR spectra were performed to insure the purity of the prepared compounds.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Organometallic Compounds / Surface-Active Agents / Surface Properties / Surface Tension / Humans / Tumor Cells, Cultured / Cobalt / Copper / Quaternary Ammonium Compounds / Animals Language: English Journal: J Cancer Res Ther Journal subject: Neoplasms / Therapeutics Year: 2007 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Organometallic Compounds / Surface-Active Agents / Surface Properties / Surface Tension / Humans / Tumor Cells, Cultured / Cobalt / Copper / Quaternary Ammonium Compounds / Animals Language: English Journal: J Cancer Res Ther Journal subject: Neoplasms / Therapeutics Year: 2007 Type: Article