Incrimination of Schistosoma spindale as a causative agent of farmer's dermatitis in Assam with a note on liver pathology in mice.

ABSTRACT

Cercarial dermatitis of paddy field workers in Assam is very common. However, it is not known which species of animal schistosomes, is its causative agent in Assam. Studies in two dermatitis affected villages of Dibrugarh district revealed that cercariae of Schistosoma spindale were involved in its aetiology. Indoplanorbis exustus was the only snail species found infected with apharyngeate brevifurcate schistosome cercarie. Experimental infection of the laboratory animals with the dermatitis causing schistosome cercariae revealed that duckling and chicken were refractory to infection. However, Swiss albino mice were successfully infected. The number of adult flukes per infected mice ranged from 6-321 (mean intensity = 68.1; S.D. = +/- 112.96). Histopathological study of infected mice liver revealed that there was mild inflammation of infected portal triads towards the presence of male flukes in the intra hepatic portal vessels. Kuppffer cells showed hyperplasia and contained large amounts of black pigment. No eggs or egg granulomas were detected in the liver parenchyma. There was no evidence of thrombophlebitis, septal fibrosis or pipe stem fibrosis.