Artemether vs quinine therapy in Plasmodium falciparum malaria in Manipur--a preliminary report.
Article
in English
| IMSEAR
| ID: sea-111967
ABSTRACT
Qinghaosu and its derivatives are rapidly effective antimalarial drugs derived from a Chinese plant (sweet worm wood). Preliminary studies suggest that these drugs may be more effective than quinine in the treatment of Plasmodium falciparum malaria. A randomised double blind trial was conducted in 52 cases of Plasmodium falciparum malaria cases. In all 26 cases were given artemether and another 26 were given quinine. There were 2 (7.5%) deaths in artemether group and 4 (15%) deaths in quinine group. The parasites were cleared more quickly from the blood in artemether group when compared to quinine group (mean-72 hrs vs 96 hrs). Resolution of fever was comparable in both artemether and quinine group (mean-84 hrs vs 78 hrs) and also the average time of recovery from coma was more earlier in artemether group (mean-60 hrs vs 72 hrs). The only side effect noticed with artemether therapy was gastrointestinal (GI) intolerance while quinine therapy was associated with myocarditis, hypotension, hypoglycemia and GI intolerance.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium falciparum
/
Quinine
/
Sesquiterpenes
/
Female
/
Humans
/
Male
/
Double-Blind Method
/
Adolescent
/
Malaria, Falciparum
/
Adult
Type of study:
Controlled clinical trial
Country/Region as subject:
Asia
Language:
English
Year:
2001
Type:
Article
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