Comparative evaluation of blood schizontocidal activity of quinine and quinidine against drug resistant rodent malaria.

Kazim, M; Puri, S K; Dutta, G P

Kazim, M; Puri, S K; Dutta, G P.

Article in English | IMSEAR | ID: sea-112153

ABSTRACT

ABSTRACT

Blood schizontocidal activity of quinine and quinidine has been compared against sensitive as well as chloroquine/mefloquine/quinine resistant strains of Plasmodium berghei and a multiple resistant strain of P. yoelii nigeriensis in Swiss mice. Evaluation of results on ED50/ED90 basis has shown distinct superiority of quinidine over quinine against sensitive as well as drug resistant strain of rodent malaria.

Subject(s)

Animals; Drug Evaluation, Preclinical; Drug Resistance; Malaria/blood; Mice; Plasmodium berghei; Plasmodium yoelii; Quinidine/administration & dosage; Quinine/administration & dosage

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plasmodium berghei / Quinidine / Quinine / Drug Resistance / Plasmodium yoelii / Drug Evaluation, Preclinical / Animals / Malaria / Mice Language: English Year: 1991 Type: Article

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