Role of macrophages in experimental malaria: VI--Effect of Freund's complete adjuvant in Plasmodium berghei infected mice.
Article
in English
| IMSEAR
| ID: sea-113032
ABSTRACT
Freund's complete adjuvant (FCA) treated group of mice when challenged with lethal Plasmodium berghei showed increased survival value; survival period (SP) and median survival day (MSD) compared to their respective control groups. K values were affected and mean parasitaemia during infection period was lower than that of control. In general survival rate after 35 days of infection was 10.5% in FCA recipients. The survival rate in a particular group of animals which received 0.2 ml FCA 3 days before challenge was 22.7%. FCA was found to contribute to increased survival of the host against P. berghei infection. The study indicates that adjuvants, like FCA induce protective immunity and future studies should include non-specific immunization against human malaria.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plasmodium berghei
/
Humans
/
Male
/
Freund's Adjuvant
/
Animals
/
Macrophages
/
Malaria
/
Mice
Language:
English
Year:
1999
Type:
Article
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