Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats.
J Environ Biol
;
2007 Oct; 28(4): 833-7
Article
in English
| IMSEAR
| ID: sea-113181
ABSTRACT
Diabetes mellitus is a worldwide leading metabolic syndrome, associated with profound alterations in carbohydrate, lipids, lipoproteins and protein metabolisms. Worldwide, traditional practitioners for the treatment of diabetes and its complications use a wide variety of medicinal plants. In the present study the aqueous extract of Tephrosia purpurea leaves (TpALet) was evaluated for its antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats. Profound alterations in the concentrations of blood glucose, lipids and lipoproteins were observed in diabetic rats. Oral administration of TpALet to diabetic rats at a dose of 600 mg/kg body weight significantly reduced the level of blood glucose and increased the level of plasma insulin as well as normalized the lipids and lipoproteins profile. The present study thus demonstrated that TpALet has prominent antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Blood Glucose
/
Male
/
Rats, Wistar
/
Streptozocin
/
Plant Leaves
/
Tephrosia
/
Diabetes Mellitus, Experimental
/
Hypoglycemic Agents
/
Insulin
Language:
English
Journal:
J Environ Biol
Year:
2007
Type:
Article
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