Role of Tribulus terrestris (Linn.) (Zygophyllacea) against mercuric chloride induced nephrotoxicity in mice, Mus musculus (Linn.).
J Environ Biol
;
2006 May; 27(2 Suppl): 397-400
Article
in English
| IMSEAR
| ID: sea-113249
ABSTRACT
The present study investigates the influence of methanolic fraction (MF) of Tribulus terrestris fruit extract on the kidney tissues of mercury intoxicated mice, Mus musculus. At median-lethal dose of mercuric chloride (12.9 mg/kg body weight), the whole kidney tissue showed an increased level of lipid peroxidation (LPO), glutathione peroxidase (GPx) activities and simultaneously a decreased level of superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH). These parameters reached to near normal after administration of fruit extracts of T. terrestris for 7 days. The results suggested that the oral administration of methanolic fraction of Tribulus terrestris fruit extract at dose 6 mg/kg body weight provided protection against the mercuric chloride induced toxicity in the mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Superoxide Dismutase
/
Female
/
Plant Extracts
/
Lipid Peroxidation
/
Catalase
/
Zygophyllaceae
/
Glutathione
/
Glutathione Peroxidase
/
Kidney
/
Lethal Dose 50
Language:
English
Journal:
J Environ Biol
Year:
2006
Type:
Article
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