Effect of DDVP on the histology and AChE kinetics of heart muscles of Rattus norvegicus.
J Environ Biol
;
2001 Oct; 22(4): 257-61
Article
in English
| IMSEAR
| ID: sea-113293
ABSTRACT
The LD50 of DDVP (Dichloro, dimethyl vinyl phosphate) for Rattus norvegicus was 21.4 mg/kg. b.w. The two sub lethal doses 1 and 3 mg/kg showed many histopathological changes in the working heart muscles and also showed significant necrosis in this S-A node, A-V node and bunble of His of the cardiac conducting system. These sublethal doses of the OP pesticide caused a significant inhibition of AChE. The maximum inhibition was noticed at the highest dose. The enhanced inhibitory constant Km and ACh contents in the heart muscles with the increase of dose showed inhibition of enzyme. The constant Vmax showed competitive nature of inhibition. A significant inhibition of AChE (69%) indicated that DDVP is a strong inhibitor of enzyme in heart.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Acetylcholinesterase
/
Rats
/
Male
/
Kinetics
/
Dichlorvos
/
Dose-Response Relationship, Drug
/
Insecticides
/
Animals
/
Myocardium
Language:
English
Journal:
J Environ Biol
Year:
2001
Type:
Article
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