The effect of lead bioaccumulation on haem biosynthetic enzymes in fish.
J Environ Biol
;
2003 Jul; 24(3): 271-80
Article
in English
| IMSEAR
| ID: sea-113301
ABSTRACT
The bioaccumulations of lead in the liver and hepatic microsomes of fish after 1, 3, 7, 14, 28, and 45 days exposure were studied. In addition, the relationship between the bioaccumulated lead in both hepatic microsomes and the liver and their haem biosynthetic enzymes were studied. Lead toxicity was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal cytochrome P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. The activity of the rate-limiting enzyme of haem biosynthesis, delta-aminolevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. The activity of the heam biosynthetic enzymes delta-aminolevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. The activity of the haem catabolic enzyme, haem oxygenase, was increased by concentration and length of time to lead exposure.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Water Pollutants
/
Carps
/
Microsomes, Liver
/
Cytochrome P-450 Enzyme System
/
5-Aminolevulinate Synthetase
/
Heme
/
Lead
/
Animals
Language:
English
Journal:
J Environ Biol
Year:
2003
Type:
Article
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