Antigenotoxic effect of allicin against methyl methanesulphonate induced genotoxic damage.
J Environ Biol
;
2005 Jul; 26(3): 547-50
Article
in English
| IMSEAR
| ID: sea-113348
ABSTRACT
Allicin, one of the sulfur compounds especially thiosulphonates of garlic (Allium sativum), possesses antioxidant and thioldisulphide exchange activity and is also shown to cause a variety of actions potentially useful for human health. In this investigation we determined its antigenotoxic potential using chromosomal aberrations (CAs) and sister chromatid exchanges (SCEs) induced by methyl methanesulphonate (MMS) as genotoxic end points both in the presence as well as absence of rat liver microsomal activation system (S9 mix) in cultured human lymphocytes. We tested the effect of 5, 10 and 20 microM of allicin on the damage exerted by 60 microM of MMS. The levels of CAs and SCEs were lowered suggesting an antigenotoxic role of allicin against genotoxic damage both in the presence as well as absence of metabolic activation.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Recombination, Genetic
/
Sulfinic Acids
/
Humans
/
Microsomes, Liver
/
Lymphocytes
/
Chromosome Aberrations
/
Dose-Response Relationship, Drug
/
Animals
/
Methyl Methanesulfonate
Language:
English
Journal:
J Environ Biol
Year:
2005
Type:
Article
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