Pre-administration of beta-carotene protects tissue glutathione and lipid peroxidation status following exposure to gamma radiation.
J Environ Biol
;
2003 Oct; 24(4): 369-72
Article
in English
| IMSEAR
| ID: sea-113821
ABSTRACT
The present study has been aimed to investigate the protective effect of beta-carotene against radiation-induced oxidative stress in mice tissues using lipid peroxidation and glutathione (GSH) as end points. Fourteen days oral priming administration of beta-carotene (35 mg/kg body weight) followed by an acute dose of gamma radiation (5 Gy) inhibited the augmented level of thiobarbituric acid reactive substance (TBARS) and a statistically significant protection against GSH depletion. Results evaluated from this study clearly indicate the antioxidative property of beta-carotene against gamma radiation, which is suggestive of free radical scavenging and singlet oxygen quenching.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Spleen
/
Testis
/
Brain
/
Male
/
Lipid Peroxidation
/
Thiobarbituric Acid Reactive Substances
/
Beta Carotene
/
Gamma Rays
/
Glutathione
/
Kidney
Language:
English
Journal:
J Environ Biol
Year:
2003
Type:
Article
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