Conscious sedation--an artist's science! An Indian experience with midazolam.
J Indian Soc Pedod Prev Dent
;
2006 Mar; 24(1): 7-14
Article
in English
| IMSEAR
| ID: sea-114973
ABSTRACT
The present study was undertaken to evaluate Midazolam as a Paediatric conscious sedative agent for a routine Indian dental setup and to compare its efficacy and safety when administered by intranasal and intramuscular routes, at a dosage of 0.2 mg/kg body weight. The present study was accomplished in two phases Phase 1 Preliminary dose finding pilot study on 10 children. Phase 2 Single dose, randomized parallel clinical trial on 40 children between the ages of 2 and 5 years. These children were randomly assigned to two groups consisting of 20 subjects each. Group M, received Midazolam intramuscularly, while Group N received Midazolam intranasally. Both the intranasal and intramuscular groups showed highly significant decrease in crying levels, motor movements and sensory perception levels, post-sedation (P P < 0.001). Midazolam could be safely and successfully employed by intranasal and intramuscular routes for Paediatric conscious sedation in a routine dental setup with basic facilities at a dosage of 0.2 mg/ kg body weight. Whenever the clinical situation warrants a faster action, peak and recovery, the intranasal route should be the obvious choice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Safety
/
Sneezing
/
Time Factors
/
Wakefulness
/
Body Weight
/
Midazolam
/
Anesthesia Recovery Period
/
Female
/
Humans
/
Male
Type of study:
Controlled clinical trial
Language:
English
Journal:
J Indian Soc Pedod Prev Dent
Journal subject:
Dentistry
Year:
2006
Type:
Article
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