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Conscious sedation--an artist's science! An Indian experience with midazolam.
J Indian Soc Pedod Prev Dent ; 2006 Mar; 24(1): 7-14
Article in English | IMSEAR | ID: sea-114973
ABSTRACT
The present study was undertaken to evaluate Midazolam as a Paediatric conscious sedative agent for a routine Indian dental setup and to compare its efficacy and safety when administered by intranasal and intramuscular routes, at a dosage of 0.2 mg/kg body weight. The present study was accomplished in two phases Phase 1 Preliminary dose finding pilot study on 10 children. Phase 2 Single dose, randomized parallel clinical trial on 40 children between the ages of 2 and 5 years. These children were randomly assigned to two groups consisting of 20 subjects each. Group M, received Midazolam intramuscularly, while Group N received Midazolam intranasally. Both the intranasal and intramuscular groups showed highly significant decrease in crying levels, motor movements and sensory perception levels, post-sedation (P P < 0.001). Midazolam could be safely and successfully employed by intranasal and intramuscular routes for Paediatric conscious sedation in a routine dental setup with basic facilities at a dosage of 0.2 mg/ kg body weight. Whenever the clinical situation warrants a faster action, peak and recovery, the intranasal route should be the obvious choice.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Safety / Sneezing / Time Factors / Wakefulness / Body Weight / Midazolam / Anesthesia Recovery Period / Female / Humans / Male Type of study: Controlled clinical trial Language: English Journal: J Indian Soc Pedod Prev Dent Journal subject: Dentistry Year: 2006 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Safety / Sneezing / Time Factors / Wakefulness / Body Weight / Midazolam / Anesthesia Recovery Period / Female / Humans / Male Type of study: Controlled clinical trial Language: English Journal: J Indian Soc Pedod Prev Dent Journal subject: Dentistry Year: 2006 Type: Article