Neostigmine does not prolong the duration of analgesia produced by caudal bupivacaine in children undergoing urethroplasty.
J Postgrad Med
;
2007 Jul-Sep; 53(3): 161-5
Article
in English
| IMSEAR
| ID: sea-115895
ABSTRACT
CONTEXT Neostigmine extends the duration of analgesia produced by caudal bupivacaine in children. AIMS:
To study the effect of different doses of caudal neostigmine on the duration of postoperative analgesia. SETTINGS ANDDESIGN:
A randomized, double-blind study was conducted in 120 boys aged 1-12 years undergoing urethroplasty under combined general and caudal anesthesia. MATERIALS ANDMETHODS:
Children were administered 1.875 mg/kg bupivacaine alone (Group B) or with 2, 3 or 4 microg/kg of neostigmine (groups BN 2, BN 3 or BN 4 respectively) as caudal drug (0.75 ml/kg). Children with a pain score of 4 or more (OPS and NRS) postoperatively were administered rescue analgesic. Time to first analgesic and the number of analgesic doses administered in the 24h were recorded. STATISTICALANALYSIS:
Parametric data were analyzed using ANOVA. Kaplan-Meier survival curves for the time to first analgesic administration were plotted and compared using log rank analysis. Chi-square test was used to analyze the incidence data.RESULTS:
The median [IQR] time to first analgesic in Group B (540 [240-1441] min) was similar to that in Groups BN 2 (450 [240-720]), BN 3 (600 [360-1020]) and BN 4 (990 [420-1441]). Significantly more patients in Groups B (9 [34.6%]) and BN 4 (13 [44.8%]) required no supplemental analgesic for 24h than those in Groups BN 2 and BN 3 (4 [13.8%] and 4 [13.3%]). The number of analgesic doses required in 24h in the four groups was similar.CONCLUSION:
Addition of neostigmine to 1.875 mg/kg of caudal bupivacaine did not prolong the analgesia following urethroplasty in children.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Urologic Surgical Procedures, Male
/
Urethra
/
Bupivacaine
/
Humans
/
Male
/
Child
/
Child, Preschool
/
Double-Blind Method
/
Cholinesterase Inhibitors
/
Drug Synergism
Type of study:
Controlled clinical trial
Language:
English
Journal:
J Postgrad Med
Year:
2007
Type:
Article
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