Oral cancer among patients under the age of 35 years.
J Postgrad Med
;
2001 Jul-Sep; 47(3): 171-6
Article
in English
| IMSEAR
| ID: sea-116345
ABSTRACT
BACKGROUND:
Cancer of the oral cavity is one of the commonest cancers among males.AIMS:
To assess the aetiological factors, patient characteristics, treatment and the outcome in young patients with oral cancer. SETTINGS ANDDESIGN:
A retrospective descriptive study of patients under the age of 35 years with cancer of the oral cavity treated between 1982-1996, with the last follow-up till 2001, using the tumour registry data of Regional Cancer Centre (RCC), Trivandrum, Kerala, India. SUBJECT ANDMETHOD:
The detailed clinical, treatment and follow-up data were obtained from the computerised records of RCC and recorded on a preset proforma. This was analysed with emphasis on age, sex, risk factors, site, histology, clinical extent and treatment methods and survival in the study group. STATISTICALANALYSIS:
The survival analysis was carried by Kaplan-Meier method and the difference in survival was analysed using log-rank test.RESULTS:
Out of 264 patients analysed, tongue was the commonest site identified in 136 (52%) patients followed by buccal mucosa in 69 (26%) patients. A male female ratio of 2.31 was observed with a significantly higher male preponderance in buccal mucosa (4.31). Prior exposure to tobacco or alcohol was noted in 59.4% patients, with more habitués in buccal mucosa cancer. Histological confirmation was present only in 83.7% patients and among them most were squamous cell carcinoma (85.9%). Radiotherapy, surgery or combined modalities of treatment were employed for majority of patients. The 5-year survival was 57.3%. T stage of the tumour was found to be significant in predicting disease free survival (P=0.03).CONCLUSIONS:
The importance of early detection for clinical down staging is stressed. There is a need to investigate the aetiology of intra oral cancers in younger patients since a significant proportion (almost 40%) of these patients do not have associated risk factors for cancer.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Time Factors
/
Female
/
Humans
/
Male
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Survival Analysis
/
Retrospective Studies
/
Risk Factors
/
Follow-Up Studies
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Country/Region as subject:
Asia
Language:
English
Journal:
J Postgrad Med
Year:
2001
Type:
Article
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