Antiretroviral drug resistance testing.
J Postgrad Med
;
2006 Jul-Sep; 52(3): 187-93
Article
in English
| IMSEAR
| ID: sea-116804
ABSTRACT
While antiretroviral drugs, those approved for clinical use and others under evaluation, attempt in lowering viral load and boost the host immune system, antiretroviral drug resistance acts as a major impediment in the management of human immune deficiency virus type-1 (HIV-1) infection. Antiretroviral drug resistance testing has become an important tool in the therapeutic management protocol of HIV-1 infection. The reliability and clinical utilities of genotypic and phenotypic assays have been demonstrated. Understanding of complexities of interpretation of genotyping assay, along with updating of lists of mutation and algorithms and determination of clinically relevant cut-offs for phenotypic assays are of paramount importance. The assay results are to be interpreted and applied by experienced HIV practitioners, after taking into consideration the clinical profile of the patient. This review sums up the methods of assay currently available for measuring resistance to antiretroviral drugs and outlines the clinical utility and limitations of these assays.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenotype
/
Humans
/
Microbial Sensitivity Tests
/
Acquired Immunodeficiency Syndrome
/
HIV-1
/
Anti-HIV Agents
/
Drug Resistance, Viral
/
Genotype
/
Mutation
Type of study:
Practice guideline
Language:
English
Journal:
J Postgrad Med
Year:
2006
Type:
Article
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