Outcomes of renal transplantation in patients with immunoglobulin A nephropathy in India.
J Postgrad Med
;
2007 Apr-Jun; 53(2): 92-5
Article
in English
| IMSEAR
| ID: sea-116823
ABSTRACT
BACKGROUND:
There is a paucity of data on the course of renal transplant in patients with immunoglobulin A (IgA) nephropathy (IgAN) from India. While the natural history of IgAN in the Indian context is rapidly progressive, the post-transplant course remains speculative.AIM:
To study the graft survival in renal transplant recipients whose native kidney disease was IgAN and the incidence and correlates of recurrent disease. SETTINGS AND DESIGNS Retrospective case control study from a Nephrology unit of a large tertiary care center. MATERIALS ANDMETHODS:
The outcomes of 56 transplant patients (58 grafts) with biopsy-proven IgAN and of 116 patients without IgAN or diabetic nephropathy, transplanted during the same period were analyzed. Correlates of biopsy-confirmed recurrent disease were determined. STATISTICALANALYSIS:
Means were analyzed by Student's t test and Mann-Whitney test; proportions were determined by Chi-square analysis and graft survival curves were generated using the Kaplan-Meier.RESULTS:
Five-year graft survival for IgA patients was not significantly different from that in the reference group (90% and 79%, P = 0.6). During a mean follow-up of 42 months (range, 1-144), 28 event graft biopsies were required in 20 grafts of IgAN. Histological recurrence was diagnosed in five of the 20 available biopsies (25%) after a mean duration of 28 months. Recurrence did not correlate with donor status, HLA B35 and A2, recipient age, gender or immunosuppression.CONCLUSIONS:
Renal transplantation is an appropriate treatment modality for IgA nephropathy patients with end-stage renal disease in India, despite the potential for recurrent disease. The posttransplant course is an indolent one when compared to the malignant pretransplant phase.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Recurrence
/
Female
/
Humans
/
Male
/
Kidney Transplantation
/
Adult
/
Glomerulonephritis, IGA
/
Graft Survival
Type of study:
Observational study
/
Risk factors
Language:
English
Journal:
J Postgrad Med
Year:
2007
Type:
Article
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