Immunotherapeutic modulation of intraperitoneal adhesions by Asparagus racemosus.
J Postgrad Med
;
1989 Oct; 35(4): 199-203
Article
in English
| IMSEAR
| ID: sea-117374
ABSTRACT
The hypothesis that macrophages appear to play a pivotal role in the development of intraperitoneal adhesions and that modulation of macrophage activity, therefore, is likely to provide a tool for prevention of adhesions, was tested in the present study. Effect of Asparagus racemosus, an indigenous agent with immunostimulant properties, was evaluated in an animal model of intraperitoneal adhesions induced by caecal rubbing. Animals were sacrificed 15 days following surgery. The peritoneal macrophages were collected to assess their activity. At the same time, peritoneal cavity was examined for the presence of adhesions, which were graded. A significant decrease was observed in the adhesion scores attained by animals receiving Asparagus racemosus. This was associated with significant increase in the activity of macrophages (70.1 +/- 2.52), compared to that in surgical controls (53.77 +/- 10.8). These findings support our hypothesis and provide a novel approach for the prevention and management of post-operative adhesions.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Peritoneal Diseases
/
Plants
/
Rats
/
Female
/
Male
/
Cecal Diseases
/
Tissue Adhesions
/
Adjuvants, Immunologic
/
Animals
/
Macrophage Activation
Type of study:
Prognostic study
Language:
English
Journal:
J Postgrad Med
Year:
1989
Type:
Article
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