Hemostasis in acquired hemophilia--role of intracavitary instillation of EACA.

Sahu, S; Raipancholia, R; Pardiwalla, F K; Pathare, A V

Sahu, S; Raipancholia, R; Pardiwalla, F K; Pathare, A V.

J Postgrad Med ; 1996 Jul-Sep; 42(3): 88-90

Article in English | IMSEAR | ID: sea-117488

ABSTRACT

ABSTRACT

An 82 year old man developed antibodies against coagulation factor VIIIC without any apparent cause. Bleeding from the soft tissue cavity could not be controlled by factor VIIIC concentrates, immunosuppression with steroids and intravenous immunoglobulin therapy in the standard dosages. However, a single injection of Epsilon Aminocaproic Acid (EACA) instilled into the cavity under aseptic precautions achieved lasting hemostasis with resultant wound healing.

Subject(s)

Aminocaproic Acid/therapeutic use; Aged; Aged, 80 and over; Antifibrinolytic Agents/therapeutic use; Autoantibodies/immunology; Factor VIII/immunology; Hemophilia A/complications; Hemorrhage/drug therapy; Humans; Instillation, Drug; Male

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Autoantibodies / Aged, 80 and over / Instillation, Drug / Aged / Humans / Male / Factor VIII / Aminocaproic Acid / Hemophilia A / Hemorrhage Limits: Aged80 Language: English Journal: J Postgrad Med Year: 1996 Type: Article

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