Concerns on the dosing of antitubercular drugs for children in RNTCP.
Indian Pediatr
;
2008 Oct; 45(10): 852-4
Article
in English
| IMSEAR
| ID: sea-11795
ABSTRACT
The Revised National Tuberculosis Control Program (RNTCP) has initiated provision of antitubercular therapy for children with strategy of patient-wise boxes for the 4 different weight bands (6- 10 kg; 11- 17 kg; 18- 25 kg; 26- 30 kg). We evaluated the dose of individual drugs delivered by this approach to children of varying weights. The following areas of concern were identified underdosing of individual antitubercular drugs for many weights; lack of provision to modify doses when child gains weight and moves to another weight band; and, inappropriate formulations, particularly for infants. We conclude that the current dosing strategy used in RNTCP needs modification to prevent the significant risk of underdosing and undertreatment.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Tuberculosis
/
Body Weight
/
Humans
/
Communicable Disease Control
/
Clinical Protocols
/
India
/
National Health Programs
/
Antitubercular Agents
Type of study:
Practice guideline
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
2008
Type:
Article
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