Prevalence of markers of transfusion transmissible diseases in voluntary and replacement blood donors.
Article
in English
| IMSEAR
| ID: sea-118162
ABSTRACT
BACKGROUND:
Transfusion of safe blood requires a safe donor. The voluntary donor movement encompasses the concept of a donor who is free from transfusion transmissible infections. It is now mandatory to screen blood for hepatitis B surface antigen, antibodies to HIV-1 and HIV-2, antibodies to hepatitis C virus, syphilis and malarial parasites.METHODS:
Between 1996 and 2002, 235 461 donors were screened for markers of hepatitis B virus, and HIV-1 and HIV-2 using commercially available ELISA kits, VDRL test for syphilis and Geimsa stain for the malarial parasite, respectively. A total of 56 476 donors were screened for hepatitis C virus antibodies from June 2001 to December 2002, using third-generation ELISA kits.RESULTS:
The proportion of voluntary donors increased from 47% to 56% during the study period. The prevalence of HIV showed a steady increase from 0.16% in 1996 to 0.3% in 2002. The prevalence of hepatitis B surface antigen decreased from 1.55% to 0.99%. VDRL reactivity did not show any trend and ranged between 0.11% and 0.66%. Hepatitis C virus antibodies showed a prevalence of 0.4%. The prevalence of all markers was significantly less in voluntary donors. Among the voluntary donors, transfusion transmissible disease markers were significantly less in student donors as compared to other donors.CONCLUSION:
A change-over to a voluntary donor service would considerably reduce the number of infectious donors and, among voluntary donors, student donors are the safest.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Safety
/
Blood Donors
/
Blood Transfusion
/
Humans
/
Biomarkers
/
Seroepidemiologic Studies
/
Prevalence
/
Blood-Borne Pathogens
/
Disease Transmission, Infectious
/
India
Type of study:
Prevalence study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Year:
2004
Type:
Article
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