Does autopsy of antenatally diagnosed malformed foetuses aid genetic counselling?
Article
in English
| IMSEAR
| ID: sea-118418
ABSTRACT
BACKGROUND:
Many pregnancies are terminated because of ultrasonographic diagnosis of malformation in the foetus. A detailed foetal autopsy is needed to arrive at a definite diagnosis on the basis of which genetic counselling can be provided.METHODS:
Sixty-one foetuses, terminated because of antenatal diagnosis of congenital malformations by ultrasound, were autopsied. The ultrasound diagnosis was compared with the diagnosis reached after autopsy.RESULTS:
In 31 cases (51%) the autopsy provided additional findings. In 21 cases (34.4%), the autopsy changed the primary diagnosis. The revised diagnosis led to a change in the risk of recurrence in 18 cases (29.5%).CONCLUSION:
Genetic counselling depending solely on ultrasonographic foetal diagnosis may be erroneous. For appropriate genetic counselling, a detailed foetal examination should be carried out after termination in cases with ultrasonographically detected congenital malformations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Autopsy
/
Congenital Abnormalities
/
Female
/
Humans
/
Pregnancy
/
Ultrasonography, Prenatal
/
Genetic Counseling
Type of study:
Diagnostic study
Language:
English
Year:
1998
Type:
Article
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