Hyperhomocysteinemia as a risk factor for ischemic stroke: an Indian scenario.
Neurol India
;
2005 Sep; 53(3): 297-301; discussion 301-2
Article
in English
| IMSEAR
| ID: sea-120041
ABSTRACT
BACKGROUND:
Hyperhomocysteinemia has been proposed as an important risk factor for ischemic stroke worldwide, but data available from the Indian subcontinent is scarce.AIM:
To study homocysteine levels in patients with ischemic stroke and compare it with age- and sex-matched controls. SETTINGS ANDDESIGN:
Case-control prospective study. MATERIALS ANDMETHODS:
Fifty-seven patients with ischemic stroke and 30 controls were recruited for the study. They were subdivided into two subgroups (< 40 years and> 40 years of age) and plasma fasting total homocysteine (tHcy) levels were measured. STATISTICAL ANALYSIS USED Student's 't' test and chi-square test.RESULTS:
The tHcy were significantly high in patients with stroke, compared to controls (9.91 +/- 2.25 vs 8.00 +/- 2.74 micromol/l; P vs 8.45 +/- 2.72 micromol/l; P = 0.01) and female patients compared to controls (9.08 +/- 1.81 vs 6.79 +/- 2.60 micromol/l; P = 0.04). The tHcy levels were significantly high in patients with hypertension compared to normotensive patients (10.96 vs 9.49 micromol/l; P = 0.01) and smokers compared to nonsmokers (11.17 vs 9.33 micromol/l; P = 0.01).CONCLUSIONS:
Hyperhomo-cysteinemia emerged as an important independent risk factor for ischemic stroke. A strong positive correlation was also observed between hypertension, smoking, and high-tHcy levels in the present study.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Humans
/
Male
/
Case-Control Studies
/
Brain Ischemia
/
Risk Factors
/
Adult
/
Hyperhomocysteinemia
/
Stroke
/
India
Type of study:
Etiology study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Neurol India
Year:
2005
Type:
Article
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