Measuring the corpus callosum in schizophrenia: a technique with neuroanatomical and cytoarchtectural basis.
Neurol India
;
2003 Jun; 51(2): 189-92
Article
in English
| IMSEAR
| ID: sea-120855
ABSTRACT
BACKGROUND:
Corpus Callosum (CC) abnormalities have been described in schizophrenia. Review of CC measurement methods in schizophrenia reveals inconsistency and lack of neuroanatomical basis.AIMS:
The aims of the study are to describe a new CC measurement method with valid a neuroanatomical and cytoarchitectural basis and to demonstrate inter-rater reliability for the same. SETTINGS ANDDESIGN:
The study was performed in the National Institute of Mental Health & Neurosciences, Bangalore, India. Ours is a cross-sectional study in which both the first author and senior neuroradiologist were blind to clinical details. MATERIAL ANDMETHODS:
We report a reliable, semi-automated CC measuring technique with a neuroanatomical and cytoarchitectural basis tested in a group of 16 never-treated schizophrenia patients using 1-mm thick, objectively defined midsagittal MRI section. Measurement on coded slices using scion image software ensured elimination of rater bias. STATISTICAL ANALYSIS USED The statistical analysis used for assessing inter-rater reliability is intraclass correlation coefficient analysis.RESULTS:
The intraclass correlation coefficients for the CC measurements were as follows CC Area = 0.93; Anterior CC area = 0.84; Area of body of the CC = 0.83; Area of CC isthmus = 0.65; Area of CC splenium = 0.88; maximum antero-posterior distance of CC = 0.96.CONCLUSION:
Measurements showed good inter-rater reliability. The methodology demonstrated in our study is simple, relevant, reliable and can be used for future schizophrenia research.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Schizophrenia
/
Brain
/
Humans
/
Magnetic Resonance Imaging
/
Corpus Callosum
Type of study:
Controlled clinical trial
/
Observational study
Language:
English
Journal:
Neurol India
Year:
2003
Type:
Article
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