Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population.
Neurol India
;
2006 Dec; 54(4): 366-9
Article
in English
| IMSEAR
| ID: sea-121221
ABSTRACT
BACKGROUND AND AIMS:
Chronic inflammatory process plays an important role in atherothrombosis. Interleukin-1 (IL-1) is one of the key modulators of the inflammatory response and its activity is critically regulated by its receptor antagonist (IL-1Ra). A variable number tandem repeat polymorphism in intron 2 of IL-1Ra gene and a C to T single base polymorphism in the promoter of IL-1beta gene (C(-511)-->T) have been reported to affect the levels of IL-1 as well as its antagonist, IL-1Ra. It is also reported in several studies that these polymorphisms are associated with the susceptibility to cardio-cerebral vascular disease. However, data are limited in China. In this article, we studied the relationships between these polymorphisms and the risk of ischemic stroke in China. MATERIALS ANDMETHODS:
One hundred and twelve patients committed ischemic stroke were compared with 95 demographically matched healthy volunteers.RESULTS:
The frequencies of the IL-1Ra 1/1 genotype and IL-1Ra allele 1 (Ra*1 allele) in stroke patients were significantly higher than those in healthy volunteers [93.7% vs. 82.1%, P =0.014; 0.964 vs. 0.905, P =0.007]. No significant differences were found in the IL-1beta -511 genotype and the allele distribution between the two groups.CONCLUSIONS:
Our results implicated that IL-1 gene polymorphism might be associated with the susceptibility to ischemic stroke.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polymorphism, Genetic
/
Aged
/
Female
/
Humans
/
Male
/
Brain Ischemia
/
China
/
Multigene Family
/
Interleukin-1
/
Receptors, Interleukin-1
Country/Region as subject:
Asia
Language:
English
Journal:
Neurol India
Year:
2006
Type:
Article
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