Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.
Neurol India
;
1999 Jun; 47(2): 104-7
Article
in English
| IMSEAR
| ID: sea-121606
ABSTRACT
The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentration and elimination half life were significantly increased and t-max was significantly reduced, indicating the suppression of phenytoin metabolism by 'Mentat'.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenytoin
/
Plants, Medicinal
/
Psychotropic Drugs
/
Rabbits
/
Male
/
Plant Extracts
/
Dose-Response Relationship, Drug
/
Drug Interactions
/
Drug Evaluation, Preclinical
/
Animals
Language:
English
Journal:
Neurol India
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS