Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.
Neurol India
;
2001 Jun; 49(2): 144-7
Article
in English
| IMSEAR
| ID: sea-121610
ABSTRACT
Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pituitary Neoplasms
/
Aged
/
Female
/
Humans
/
Male
/
Magnetic Resonance Imaging
/
Adenoma
/
Child
/
Adolescent
/
Ki-67 Antigen
Language:
English
Journal:
Neurol India
Year:
2001
Type:
Article
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