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Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.
Neurol India ; 2001 Jun; 49(2): 144-7
Article in English | IMSEAR | ID: sea-121610
ABSTRACT
Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pituitary Neoplasms / Aged / Female / Humans / Male / Magnetic Resonance Imaging / Adenoma / Child / Adolescent / Ki-67 Antigen Language: English Journal: Neurol India Year: 2001 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pituitary Neoplasms / Aged / Female / Humans / Male / Magnetic Resonance Imaging / Adenoma / Child / Adolescent / Ki-67 Antigen Language: English Journal: Neurol India Year: 2001 Type: Article