Systemic lupus erythematosus in Indian children.
Indian Pediatr
;
1989 Sep; 26(9): 868-73
Article
in English
| IMSEAR
| ID: sea-12289
ABSTRACT
Twenty cases of systemic lupus erythematosus (SLE) in prepubertal children (less than 14 years of age) were seen over a period of 14 years. The malefemale ratio was 12.3, and the mean age at onset was 9.37 years. Fever with joint involvement was the commonest presenting manifestation (60%), followed by nephrotic syndrome (25%). Notable clinical features included a high incidence of renal involvement (75%), significant hypertension (45%) and reversibility of acute renal failure (2 cases). The other organs and systems involved included mucocutaneous manifestations (60%), cardiovascular system (30%), respiratory system (25%), neuropsychiatric manifestations (45%), and anemia (75%). Raynaud's phenomenon and thrombocytopenia were rare while leucopenia was not seen in a single patient. Immunological abnormalities noted were 100% positivity for antinuclear antibodies, and 87.5 and 75% positivity for antibodies to double-stranded and single-stranded DNA, respectively. Hypocomplementemia was seen in 75% of patients tested.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Lupus Erythematosus, Cutaneous
/
Lupus Nephritis
/
Female
/
Humans
/
Male
/
DNA
/
Child
/
Child, Preschool
/
Antibodies, Antinuclear
/
Adolescent
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
1989
Type:
Article
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