Neoadjuvant chemotherapy in advanced gastric cancer--results of a pilot study.
Article
in English
| IMSEAR
| ID: sea-124737
ABSTRACT
INTRODUCTION:
Adenocarcinoma of the stomach is usually advanced at presentation, and local or distant spread may preclude the option of primary curative resection. Neoadjuvant chemotherapy (NAC) has shown promise in downstaging initially unresectable disease. This pilot study was planned to assess the utility of NAC using Cisplatin and 5-Fluoro uracil in the management of initially unresectable gastric cancer. PATIENTS ANDMETHODS:
Ten patients with unresectable gastric adnocarcinoma were included. They received two cycles of cisplatin, 30 mg/m2 intravenously in combination with 5-Fluoro Uracil, 1000 mg/m2. They were restaged using Endoscopy and CT scan and taken up for exploratory laparotomy.RESULTS:
Eight of 10 patients (80%) had an objective response to chemotherapy. Six patients (60%) with initially unresectable disease could be offered curative surgery. The median survival was 10 months (range 1-60 months). There were two long term survivors (48 and 60 months respectively).CONCLUSION:
Neoadjuvant chemotherapy (NAC) is an effective option in downstaging initially unresectable gastric carcinoma. Complete response to chemotherapy also predicts long term survival.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stomach Neoplasms
/
Female
/
Humans
/
Male
/
Adenocarcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Pilot Projects
/
Cisplatin
/
Adult
/
Neoadjuvant Therapy
Language:
English
Year:
2002
Type:
Article
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