Non-familial juvenile polyposis with histological evidence of adenomatous transformation.
Article
in English
| IMSEAR
| ID: sea-124939
ABSTRACT
A 14-year-old male presented with abdominal pain, diarrhoea and a sensation of something prolapsing through the anus during defecation, and was found to have diffuse colonic polyposis. There was no evidence of mucocutaneous hyperpigmentation and family history was negative, suggesting a diagnosis of non-familial juvenile polyposis. Histological analysis of multiple endoscopic biopsies showed features typical of juvenile or retention type (hamartomatous) lesions dilated cystic glands lined by mucocus-secreting epithelium and prominent, inflamed and congested lamina propria. However, admixed with these features, focal areas of atypical adenomatous changes were recognized. Even the intervening normal-looking colonic mucosa showed some dysplastic changes. These findings indicate that hamartomatous and atypical adenomatous epithelial changes can co exist in non-familial juvenile polyposis and the latter may confer a risk of malignant transformation in this otherwise non-neoplastic disease.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Humans
/
Male
/
Cell Transformation, Neoplastic
/
Adolescent
/
Colonic Neoplasms
/
Adenomatous Polyps
/
Intestinal Polyposis
/
Hamartoma
/
India
Country/Region as subject:
Asia
Language:
English
Year:
2004
Type:
Article
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