Characterisation of the Indian strain of duck hepatitis B virus (DHBV) and development of a carrier duck colony for antiviral drug testing.
Article
in English
| IMSEAR
| ID: sea-125271
ABSTRACT
Duck hepatitis B virus (DHBV) infected carrier ducks serve as a useful model for testing anti-hepadnavirus drugs. This needs a well characterised duck hepatitis B virus strain. We cloned and sequenced the complete genome of duck hepatitis B virus strain of Indian origin. It was 3021 nucleotides in length and had all the recognisable open reading frames (Polymerase 20-2530 nucletides, Surface 693-1787 nucleotides and Core 2518-412). Using an inoculum of 50 microliters serum containing 1 x 10(11) virus particles/ml, we could infect 80% of one day old ducklings and develop a duck colony.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Antiviral Agents
/
Molecular Sequence Data
/
Base Sequence
/
Hepatitis B Virus, Duck
/
Genome, Viral
/
Hepadnaviridae Infections
/
Ducks
/
Animals
Language:
English
Year:
1994
Type:
Article
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