Pre exposure prophylaxis of humans against rabies

ABSTRACT

The first batch of lyophilized, Sample-type,beta propiolactone inactivated anti-rabies vaccine produced by B,P .I. in 1971 was used to immuaize 55 B.P .I. workers previously unexposed to rabies and with no history of rabies vaccination. Three doses of 0.25 ml of the vaccine were given intradermally at one week intervals. Booster doses given on the 98th.' 392nd. and 592nd. Day after the first dose. Blood samples were taken and serum-virus neutralization (SN) tests were performed at varying time intervals after basic immunization and booster doses. Satisfactory antibody responses were obtained. The course of immunological response is presented in tabular and graphical form. This work was carried out from June 1971 to January 1973.