Clinical trial of low-dose aspirin in treatment of pre-eclampsia

ABSTRACT

The effectiveness of low-dose aspirin in treatment of pre-eclampsia was studied by a prospective randomized double-blind control trial. A total fifty primigravidae with pre-eclampsia (blood pressure of 160/110 mmHg or more and proteinuria of one pllus or more) were selected. They were randomly assigned to receive either 75 mg Buspro (or) placebo. Conventional treatment was given to both groups. These patients were admitted to the C.W.H up to the fifth day of puerperium. The following variable were noted blood pressure, proteinurea, blood uric acid, platelet count and bleeding time. Mode of delivery, duration of labour, neonatal outcomes and estimated blood loss due to delivery were noted. Low-dose aspirin was associated with better control of blood pressure, lower uric acid level, improved gestational age and less number of abdominal delivery, instrumental delivery (p < 0.05). Neonatal outcomes were better with improved gestational age and heavier birth weight (p < 0.05). There was no clinical evidence of abnormal bleeding in mothers and babies. changes in severity of proteinuria was not different in both groups. (p > 0.05)