Urinary fibrin(-ogen) degradation products in pregnancy associated hypertension

ABSTRACT

The relationship between the urinary fibrin(-ogen) degradation products (FOP) and high blood pressure and other features like proteinuria and oedema were studied in 42 cases of pregnancy associated hypertension (PAH) and/or pre- eclampsia (PE). Urinary FOP were detected in 64.3 per cent of cases. All cases with systolic blood pressure> 180 mmHg and/or diastolic blood pressure> 100 mmHg showed FOP in urine in various concentrations. In 91 per cent of cases with protenuria more than 2+ urinary FOP was also detected. In some cases with no proteinuria FOP was found. There was no definite relationship between severity of oedema and urinary FOP level. When a patient is under treatment and responding well to that treatment urinary FOP level also becomes reduced or undetectable.