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Clinical trial to compare the analgesic efficacy of selected Traditional Medicine Formulations (TMF-06,-24,-25) on experimentally induced pain in human subjects
Article | IMSEAR | ID: sea-126953
ABSTRACT
Forty clinically healthy volunteers participated in the study aimed to evaluate the therapeutic efficacy of three Traditional Medicine Formulations (TMF-06, TMF-24 and TMF-25) on experimentally-induced cold compressor stimulation pain. The rationale underlying the study is that these formulations have beenproduced locally and used extensively as standard analgesics for pain relief at the Traditional Medicine Hospitals and dispensaries as well as through self-medication over-the-counter-durgs by the local community for many years but has yet received little investigative attention regarding efficacy and sefety. The study was a placebo controlled double-blind, complete cross-over single dose design using aspirin (acetyl salicylate) as positive standard and was evaluated on three basic pain response parameters namely, pain threshold, pain tolerance and pain sensitivity range. All three formulations showed a significant analgesic efficacy (p < 0.01) when compared to placebo (TMF-25 > TMF-24 > TMF-60). No, adverse effects were noted even when given at maximum recomended dose. It was concluded dose. It was concluded that the three TMFs can be used as an alternative to aspirin for the symptomatic relief of mild to moderate pain.
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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Clinical Trials as Topic / Formulary / Analgesics / Medicine, Traditional Type of study: Controlled clinical trial Year: 1996 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Clinical Trials as Topic / Formulary / Analgesics / Medicine, Traditional Type of study: Controlled clinical trial Year: 1996 Type: Article