Aluminium induced microscopic changes in the kidney.

ABSTRACT

Reports of aluminium toxicity on kidneys through dietary source is less reported even though it’s adverse effects such as encephalopathy, dementia, osteomalacia and fractures have been reported in renal failure cases after ingestion of aluminium gel. As Majority of Indian population is exposed to aluminium through dietary source, therefore, the effects of alumuinium toxiciy was studied in albino rats after oral administration of Aluminium salts. The present study was carried out on 40 albino rats divided into two equal group control and experimental. Each of twenty animals of experimental group were given 37.5 mg of aluminium chloride per day orally for 3 weeks. All the animals were sacrificed on 22nd day. Small pieces of kidney were procured, fixed in 10% neutral buffered formaline and embedded in paraffin. Sections of 7µ thickness were cut and stained with Haematoxylin and Eosin for general morphology and PAS for basement membrane. Significant histopathological changes were observed. Breakdown of general architectural pattern with degenerative changes were seen more in cortex as compared to medulla. Haemorrhage and inflammatory cell reaction was also observed in cortex.