The apolipoprotein E (APOE) gene and the risk of diabetic nephropathy (DN): a meta-analysis in East Asian populations
in English
| IMSEAR
| ID: sea-129911
ABSTRACT
Background:
Several studies have examined the association between DN and the APOE gene, but the results have been inconsistent.Objective:
Determine whether APOE is a risk factor for DN by a meta-analysis.Methods:
A meta-analysis was performed using all findings of 16 similar case–control studies in East Asian to evaluate the effect of APOE as a risk factor for DN. Several electronic databases were searched for relevant articles up to 2009. After data collection, a meta-analysis was used to assess heterogeneity, combine results and evaluate variations by using software STATA SE 9.0. Publication bias was examined by the Egger’s linear regression test and fail-safe number.Results:
The meta-analysis showed that the ε2 allele almost doubled the risk of DN in East Asians (pooled ORs [95% CI] 1.85 [1.49-2.29]). In contrast, studies relating the ε4 allele to DN risk were very heterogeneous and the pooled ORs were 1.05 [95% CI 0.72-1.52]. In the subgroup meta-analysis, ε4 was substantially related to an increased risk for DN in studies conducted in China (pooled ORs [95% CI] 1.51 [1.11-2.06]), which was different from previous results. However, the higher risk of DN associated with ε4 was not found in Japanese or Korean populations (pooled ORs [95% CI] 0.46 [0.27-0.80] and 0.58 [0.09-3.55], respectively).Conclusion:
The ε2 allele conferred a higher risk of DN in East Asians, and no significant result was obtained with the ε4 allele.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Etiology study
/
Observational study
/
Risk factors
/
Systematic reviews
Language:
English
Year:
2010
Similar
MEDLINE
...
LILACS
LIS