Comparison of Two Chemotheropy Regimens (CHOP and COP) for Non-Hodgkin's Lymphoma
Article
in English
| IMSEAR
| ID: sea-133067
ABSTRACT
Abstract Comparison of Two Chemotheropy Regimens (CHOP and COP) for Non-Hodgkin's Lymphoma Saowanee Chutipong MD Anchalee Boonyaritipong MD Petch Rawdaree MD Department of Medicine, BMA Medical College and Vajira Hospital Objective:
To study efficacy of chemotherapy CHOP and COP in non-Hodgkin's lymphoma (NHL) by median survival time and mortality rate, Studydesign:
Cohort study.Subjects:
Eighty sevent patients of intermediate and high grade NHL who attend in hematology clinic, Department of Medicine, BMA Medical College and Vajira Hospital from January 1985 to March 2000.Methods:
Follow up the patients who were intermediate and high grade NHL treated continuously by CHOP regimen (cyclophosphamide, doxorubicin, vencristine and prednisolone) every month in the first group. And the second groups were treated continuously by COP regimen (cyclophosphamide, vincristine and prednisolone every month for two years. Every patient were followed up about 55 months (average). Main outcomemeasures:
Median survival time and crude mortality rate.Results:
Median survival time of CHOP group is 28 months whereas 44 months in COP group but there was no statistically significant difference (p = 0.19). The crude mortality rate in CHOP group was higher than in COP patients 1.901 time, but there was no statistically significant difference (p = 0.35). When they were adjust Kaplan-Miere curve of survival by age group and staging there was statistically significant difference, by grading there was no statistically significant difference.Conclusion:
Median survival time and crude mortality rate in this study showed no difference in efficacy of CHOP and COP treatment. When they were adjust Kaplan-Miere curve of survival by age group and staging there was statistically significant difference, by grading there was no statistically significant difference. Key words non-Hodgkin's lymphoma, chemotherapy Vajira Med J 2001 ; 45 13 - 20
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Observational study
Language:
English
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS