Hormonal Receptors Status of Breast Cancer in Northeastern Thai Women : An Analysis of 241 cases at Srinagarind Hospital

ABSTRACT

Background: The most effective treatment for  breast cancer cases  is based on an abnormal oncogene of the cancer cell and the finding of protein expression. The prognostic factor depends on  hormonal receptors status and  biological characteristics such as histological grading, tumor size or  nodal metastasis.Objective:   To study prognostic factors including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status in Northeastern Thai female breast cancer.     Materials and Methods:          A retrospective review was performed on 294 patients who have been diagnosed  with  breast cancer by hormonal study at department of Pathology, Khon Kaen University (Srinagarind hospital) during January 2004 – June 2006.Result:         The mean and median ages were 52.21 year and 53 year, respectively. The 89.83 % of the patients were  invasive ductal carcinoma and 50.93 % in histological grading II. The ER+, PR+ and HER2  positive were 53.1 %,  42.26 % and  27.15  %, respectively. The proportion of ER+PR+, ER+PR-,  ER-PR+, ER-PR-  and HER2 were  4.7, 20.5, 29.4 and  44.2 % , respectively.Conclusion: The present study showed  that  the highest chance to get HER2 positive was when both ER and PR were negative.Key words Breast Cancer, Estrogen Receptor, Progesterone Receptor, Human Epidermal Growth Factor Receptor 2