Glanzmann's thrombasthenia.
Indian Pediatr
;
1992 Jul; 29(7): 837-41
Article
in English
| IMSEAR
| ID: sea-13384
ABSTRACT
During January 1981 to June 1991, 20 patients from 16 unrelated families were detected to have Glanzmann's thrombasthenia (GT). Twelve families (75%) had history of consanguinity, with 6 first cousins and 3 uncle-niece marriages; of these 7 were Muslims, 6 Hindus and 3 Christians. There were 12 girls and 8 boys; the mean age at diagnosis was 7.05 +/- 6.03 yr (range 1 day-22 yr). All cases had initial bleeding prior to the age of 5 yr with the mean age at the initial episode of bleeding being 2.21 +/- 1.34 yr (range 1 day-5 yr). Common pattern of bleeding included epistaxis, gingival bleeding, post-traumatic bruises, menorrhagia, gastrointestinal (2 cases), post-operative (2 cases) and spontaneous bleeding (2 cases). No patient showed hemarthrosis, intracranial bleeding or hemoptysis. Menorrhagia was a serious problem necessitating repeated transfusions and hormonal therapy. Twelve cases (60%) required 1-120 units of blood transfusions while five received platelet concentrates.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Thrombasthenia
/
Female
/
Humans
/
Male
/
Infant, Newborn
/
Child, Preschool
/
Platelet Aggregation
/
Genes, Recessive
/
Hemorrhage
/
Infant
Language:
English
Journal:
Indian Pediatr
Year:
1992
Type:
Article
Similar
MEDLINE
...
LILACS
LIS