Compative Erythropietin Levelsinurine of the Anemic and Malnourished Patients

ABSTRACT

The\  24 \– hour\  urinary\  excretion\  of\  erythropoietin\  was\  biologically\  assayed\  in\  the\  33\  anemic\  patients\  and\  the\  8\  patients\  with\  protein \– energy\  malnutrition\  from\  Chiang\  Mai\  Hospital,\  Chiang\  Mai\  university,\  Thailand. The\  erythropoietic\  activity\  in\  the\  patients\’\  urine\  was\  measured\  by\  radiobiological\  technique\  in\  starved\  rats,\  comparing\  with\  that\  of\  the\  18 healthy\  subjects\  living\  in\  the\  same\  area.\  This\  investigation\  indicates\  that\ \  the\  urinary\  erythropoietin\  level\  in\  patients\  with all\  types\  of\  animas\  is\  approximately\  62\  per\  cent\  higher\  than\  in\  the\  malnourished\  patients.\  The\  average\  urinary\  erythropoietic\  activity\  of\  anemic\  patients\  is\  297 .11 \  46.95\  Co\  Units\  per\  24 \– hour\  Urine,\  While\  that\  of\  the\  patients\  with\  protein \– energy\  malnutrition\  is\  only\  187 .66\  \  16.15\  Co\  Units\  per\  24 \– hour\  Urine.\  In\  the\  case\  of\  anemic\  patients,\  the\  urinary\  erythropoietin level\  in\  patients,\  the\ \  urinary\  erythropietin\  level\  in\  aplastic\  anemia\  is\  the\  highest\  among\  the\  group,\  in\  which\  the\  average\  activity\  is\  equal\  to\  725.94  88.31\  Co\  Units\  per\  24 hour\  Urine.\