Prevalence and Clinical Features of Myasthenia Gravis only and Myasthenia Gravis with hyperthyroidism
Article
in English
| IMSEAR
| ID: sea-133943
ABSTRACT
Objective To study prevalence and clinical features of myasthenia gravis (MG) and myasthenia gravis with hyperthyroidism (MGHT) Design Case review study Setting Srinagarind hospital, Faculty of Medicine, Khon Kaen University Patienes One hundred and four patients who were diagnosed as MG and MGHT in Department of Internal Medicine service between Januay 1891 and May 1992. Measurement Prevalence of MGHT, history of fatigability, fluctuation, staging, symptoms and signs, prostigmine test and treatment by thymectomy in MG and MGHT by percentage and Z – test ( P = 0.05) Results One hundred and four records were available for review, there were 85 cases of MG and 19 cases of MGHT that made the prevalence of MGHT of 18.3%. Regarding the staging of disease, in MG group of patients only 8.2% were in stage I compared to 31.6% in MGHT group( P = 0.003). Ninty four percent of MGHT patients seeked medical attention within 1 year after having MG, but there were only 77.2% in MG patients ( P = 0.048). Concerning thymectomy, in the patients who had stage IIA and above, 58 / 78 (74.4%) were thymectized in MG group. There were only 5/13 (38.5%) in MGHT group went for thymectomy (p = 0.048). The other clinlical features were comparable. The pathological findings of 50 patients in MG group were thymic hyperplasia 34 cases (68%) , htymoma 2 cases, malignant thymoma 1 case atrophic change 5 cases and normal 8 cases. In MGHT goup were thymic hyperplasia 4 cases and involuted 1 case. Concludions The prevalence of myasthenia gravis with hyperthyroidism in our study is 18.3%, which probably is the highest among all series. There were differences in some clinical features between MG and MGHT. MGHT patients were in stage 1 more frequent, seeked medical aedical altention earlier and MGHT patients went for thymectomy less frequent.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Type of study:
Prevalence study
Language:
English
Year:
2010
Type:
Article
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