Impaired pancreatic bicarbonate secretion in chronic malnutrition.
Indian Pediatr
;
1995 Mar; 32(3): 323-9
Article
in English
| IMSEAR
| ID: sea-13508
ABSTRACT
Twenty three children with recurrent episodes of diarrhea and chronic malnutrition were studied for pancreatic duct function. Those children were subjected to pancreatic stimulation with pancreozymin and secretin. Grade I malnourished children, as per Gomez classification, formed the control group. The water output from pancreas increased in malnourished children (p < 0.05). It correlated significantly to cationic transport (p < 0.01). Sodium and potassium together accounted for significant proportion of water output in pancreatic fluid. Potassium transport increased with increasing severity of malnutrition and may be responsible for the hypokalemia observed in malnourished children. Pancreatic secretion of bicarbonate decreased in severe malnutrition inspite of increased flow rate of pancreatic secretion. This is probably due to defective bicarbonate secretion likely to be located at pancreatic duct epithelial cell membrane.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pancreatic Ducts
/
Bicarbonates
/
Humans
/
Trypsin
/
Case-Control Studies
/
Child
/
Child, Preschool
/
Chronic Disease
/
Regression Analysis
/
Protein-Energy Malnutrition
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Country/Region as subject:
Asia
Language:
English
Journal:
Indian Pediatr
Year:
1995
Type:
Article
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