The critical role of tubulointerstitium in renal disease progression.
Article
in English
| IMSEAR
| ID: sea-135128
ABSTRACT
Background:
Recent works have demonstrated that, regardless of the primary causes, tubulointerstitial (TI) fibrosis is the major cause of progression of renal failure.Objective:
To summarize the mechanisms of progression and regression of TI damage.Results:
Experimental studies have shown that there are three common processes of progressive TI damage injury, inflammation, and fibrosis. Renin angiotensin system (RAS) blocking agents could substantially decrease these lesions.Conclusion:
The fulcrum of the balance between progression and regression of TI fibrosis remains to be elucidated but would be related to the activation of RAS.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Language:
English
Year:
2008
Type:
Article
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