Hypolipidemic activity of Hibiscus rosa sinensis root in rats.
Indian J Biochem Biophys
;
2009 Dec; 46(6): 507-510
Article
in English
| IMSEAR
| ID: sea-135235
ABSTRACT
The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Polyethylene Glycols
/
Male
/
Dietary Fats
/
Plant Extracts
/
Cholesterol
/
Plant Roots
/
Hibiscus
/
Hyperlipidemias
/
Liver
/
Animals
Type of study:
Prognostic study
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2009
Type:
Article
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