Effect of curcumin and ferulic acid on modulation of expression pattern of p53 and bcl-2 proteins in 7,12-dimethylbenz[]anthracene-induced hamster buccal pouch carcinogenesis.
Indian J Biochem Biophys
;
2010 Feb; 47(1): 7-12
Article
in English
| IMSEAR
| ID: sea-135236
ABSTRACT
The modulating effect of curcumin and ferulic acid was investigated on expression pattern of apoptosis regulatory p53 and bcl-2 proteins in oral squamous cell carcinoma (OSCC). The OSCC was induced in the buccal pouch of golden Syrian hamster by painting with 0.5% 7,12-dimethylbenz[]anthracene (DMBA) three-times a week for 14 weeks. The expression pattern of p53 and bcl-2 proteins was analyzed by immunohistochemical staining. We noticed 100% tumor formation in hamsters painted with DMBA alone for 14 weeks. Overexpression of p53 and bcl-2 proteins was observed in the buccal mucosa of tumor-bearing hamsters. Oral administration of curcumin (80 mg/kg body wt) and ferulic acid (40 mg/kg body wt) to DMBA painted hamsters on days alternate to DMBA painting for 14 weeks completely inhibited tumor formation and down-regulated the expression pattern of p53 and bcl-2 proteins. Our results thus demonstrated the protective role of curcumin and ferulic acid on DMBA-induced abnormal expression of p53 and bcl-2 proteins in the buccal mucosa of golden Syrian hamsters.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Male
/
Mouth Neoplasms
/
Immunohistochemistry
/
Tumor Suppressor Protein p53
/
Cricetinae
/
Mesocricetus
/
Proto-Oncogene Proteins c-bcl-2
/
Coumaric Acids
/
Curcumin
/
9,10-Dimethyl-1,2-benzanthracene
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2010
Type:
Article
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