MAPS: An interactive web server for membrane annotation of transmembrane protein structures.
Indian J Biochem Biophys
;
2011 Apr; 48(2): 106-110
Article
in English
| IMSEAR
| ID: sea-135308
ABSTRACT
The exact positioning of the membrane in transmembrane (TM) proteins plays important functional roles. Yet, the structures of TM proteins in protein data bank (pdb) have no information about the explicit position of the membrane. Using a simple hydrophobic lipid-protein mismatch energy function and a flexible lipid/water boundary, the position of lipid bilayer for representative TM proteins in pdb have been annotated. A web server called MAPS (Membrane Annotation of Protein Structures; available at http//www.boseinst.ernet.in/gautam/maps) has been set up that allows the user to interactively analyze membrane-protein orientations of any uploaded pdb structure with user-defined membrane flexibility parameters.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Algorithms
/
User-Computer Interface
/
Humans
/
Cell Membrane
/
Computational Biology
/
Internet
/
Molecular Sequence Annotation
/
Hydrophobic and Hydrophilic Interactions
/
Lipid Bilayers
/
Membrane Proteins
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2011
Type:
Article
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