-Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode Caenorhabdtis elegans.
Indian J Biochem Biophys
;
2011 June; 48(3): 191-196
Article
in English
| IMSEAR
| ID: sea-135319
ABSTRACT
Oxidative stress and other effects induced by cypermethrin (CYP, 15 mM) and their amelioration by -tocopherol (400 M) was studied in the nematode Caenorhabditis elegans. The worms exposed for 4 h to CYP showed increased levels of reactive oxygen species (46%), H2O2 (37%) and protein carbonyls (29%), accompanied by decreased lifespan and brood size. However, exposure to both CYP and a-tocopherol resulted in diminution of above alterations with the worms exhibiting relatively lower levels of ROS (30%), H2O2 (15%), protein carbonyls (14%), altered antioxidant enzyme activities and normal lifespan and brood size. The results suggest that CYP induces oxidative stress in C. elegans and the strategy of intervention with -tocopherol could be exploited to offset this induced oxidative stress.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrethrins
/
Reactive Oxygen Species
/
Caenorhabditis elegans
/
Oxidative Stress
/
Alpha-Tocopherol
/
Protein Carbonylation
/
Hydrogen Peroxide
/
Insecticides
/
Animals
/
Antioxidants
Language:
English
Journal:
Indian J Biochem Biophys
Year:
2011
Type:
Article
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